NoMachine fully supports multi-monitors or large screen up to 4k resolution. In case of multi-monitors, the global resolution is given by the sum of resolution of each monitor. For example, if you have four monitors at 4K, the final resolution is 4x4=16 k. While it's possible to display a NoMachine remote desktop on one single monitor at 4k, it's not possible to do that on a 4-screen full/Ultra HD multi-monitor setup. Tests in our labs evidenced that the NoMachine session can be displayed up to a 2x4K resolution (H.264 generally allows up to 4K, while VP8 supports a maximum resolution of 16384x16384).

Among the improvements NoMachine has in plan to implement, there is the ability to treat each monitor of a multi-monitor set-up as an invidual monitor. This will allow to keep the screen size of each video stream under reasonable limits and use H.264 (up to 4K monitors) as well as display the session on large monitors.

Besides the encoding, another possible problem can be the maximum memory size that a 32bit process can allocate on Windows. This limitation can be overriden only by NoMachine packages built for Windows 64bit architecture, available since NoMachine v.8.